DIFFERENTIAL DIAGNOSIS OF HEREDITARY KIDNEY DISEASES IN CHILDREN USING NON-INVASIVE MARKERS OF DAMAGE

Aim. To develop the diagnostic method to determine the likelihood of a specific hereditary kidney disease. Material and methods. KIM-1, TGF-β1, RBP, β2-MG, creatinine, daily proteinuria (Pt) and GFR were determined in 23 patients with hereditary nephritis and 19 patients with tubulopathies. The average age at the time of the study was 13.5 (9-17) years. The ratio of boys/girls (%) was 24:18 (57.1:42.9). Results. The distribution of factors in the groups was considered. Statistically significant differences were found in terms of serum TGF-β1 and daily Pt. According to the results of mono-factor analysis, the factors that confirmed the prognostic significance were selected: urinary β2-MG (OR = 0.892 (0.696-1.175)), serum TGF-β1 (OR = 1.01 (1.002-1.018)) and daily Pt (OR = 25 (1.774-350)). For these factors the threshold values were calculated: urinary β2-MG = 0, serum TGF-β1>280, daily Pt>0.8. The nomogram and classification scheme were built on the basis of the mathematical model for the practical application. Conclusion. As a result of the study, 3 factors were established and 2 from these 3 markers were non-invasive (urinary β2-MG and daily proteinuria). The use of these markers makes possible to diagnose hereditary nephritis in children with high accuracy.