A Case Report of Cisplatin-Induced Cardiotoxicity: A Side Effect to Moni-tor Closely

Cisplatin-induced cardiotoxicity is a well describe effect with a low incidence. Supraventricular arrhythmias and coro-nary artery disease are the main cardiac effects. Mechanism by cisplatin induced cardiac toxicity is not well understood. We present a case of asymptomatic transient sinus node dysfunction and decrease left ventricle systolic function as manifestation of cisplatin-acute cardiotoxicity in a 28-year-old female affected by Hodgkin lymphoma treated 6 years before with anthracyclines and mediastinal radiation. These are cisplatin effects rarely describe, being usually acute, reversible and transitoriness. Individual predisposition, administration in combination with other cardiotoxic drugs and previous exposition at anthracyclines and mediastinal radiation are the main risk factor to development of left ventricle systolic dysfunction. Although cisplatin is considered cardio-safe and no cardiac monitoring is generally recommended for its use, our report is important to remind to specialists that usually use cisplatin the importance of prevent, detect and monitor left ventricle systolic dysfunction in patients with these risk factors.