Role of Oxidative Stress on Age and Gender

Background: Old age is an incurable disease which is more affected by the oxidative stress by damaging the DNA and disruptions in normal mechanisms of cellular signaling. There are dates which show possible role of oxidative stress and disturbance in antioxidant mechanisms in various disorders. Materials and Methods: A cross-sectional study was undertaken for a period of 12 months with clinically normal 109 subjects at the Narayana General Hospital, Nellore. Were divided into 6 groups (decade a group) and target for the level of Malondialdehyde (MDA) a lipid peroxidation product and marker of oxidative stress and protein carbonyls (PCO) levels reflects the protein oxidation process. Reduced Glutathione (GSH) is a representative of antioxidant potency of glutathione system in erythrocytes, and Uric acid (UC) for the antioxidative capacity. Result: Increased MDA, PCO, and uric acid levels. Decreased GSH levels were found. MDA and PCO significantly positively correlated. GSH significantly negatively correlated. UC was not associated with age. MDA, PCO, and GSH levels are independents of age. UC have significant gender difference. MDA and PCO were having strong negative correlation with GSH. MDA, PCO, and UC levels are significantly high in above 50 years compared to blow 50 years. GSH levels are significantly low in above 50 years compared to blow 50 years. Conclusion: Oxidative stress (MDA & PCO) increases with age and antioxidant activity (GSH) decreases with age. Uric acid (antioxidant) increases with age but gender difference is seen. Oxidative damage in the cell is accumulating with age and there is simultaneous decrease in the antioxidant capacity. Thus, Oxidative stress is considered as one of the causes for Aging and Age related diseases.