Treatment of Chronic Hepatitis C: An Experience Report from a Referral Center in Northeastern Brazil
Journal: International Journal of Chronic Diseases & Therapy (IJCDT) (Vol.6, No. 2)Publication Date: 2020-07-15
Authors : Auzelivia Pastora Rego Medeiros Falcão Priscilla Megumi Haibara Fernando Henrique Destafani deSouza Géssika Lanzillo de Almeida Nunes Joyce Almeida Sá de Moraes AmáliaCinhtiaMeneses Rêgo Irami Araújo-Filho;
Page : 102-106
Keywords : Hepatitis C; Hepatic Cirrhosis; Liver Fibrosis; Liver Disease; Sustained Virologic Response; Sustained Viral Suppression; Antiviral Drugs.;
Abstract
Background: Therapy for the hepatitis C virus (HCV) has undergone a revolution with the introduction of direct-acting antivirals (DAA). DAAs achieve sustained virological response (SVR) in 90-95% of treated patients, compared to 50-70% of those receiving dual pegylated interferon and ribavirin therapy. Although they are already available, there are few studies on DAAs efficacy in the Brazilian population. Objective: To evaluate the efficacy of DAAs in individuals with hepatitis C at the Liver Study Center (LSC) in Hospital Universitário Onofre Lopes (HUOL). Methods: Medical records of chronic HCV patients treated with DAAs from LSC were analyzed. Only those patients with a follow-up of at least 12 weeks after the end of treatment were included. Results: A total of 50 patients underwent treatment with DAAs at LSC. Of these, genotype 1 was present in 39 patients (81.2%, 1a8.3%, 1b68.7%), genotype 2, in 2 patients (4.2%) and genotype 3, in 6 patients (14.5%, 3a 2%). Thirty-two were cirrhotic (64%), and 20 were treatment-experienced (40%). The therapeutic regimens used were mainly sofosbuvir (SOF) + simeprevir (SMV) in 23 patients (46%) and SOF + daclatasvir (DCV), in 22 (44%). SVR-12 was achieved in 92% of patients. Four patients had virological failure: three of them were cirrhotic and treatment experienced. The other one had advanced liver fibrosis (F3) with no previous treatment for HCV infection. No adverse events were reported during DAA treatment. Conclusion: The experience of the LSC with DAAs showed a high rate of SVR and excellent tolerability.
Other Latest Articles
- Factors Influencing Condom Use for the Prevention of Pregnancy and HIV Infection among Teenagers In Kampangpeth Province, Thailand
- Effect of Yoga on Anxiety
- Effectiveness of a Program for Promoting Physical Activity to Prevent Obesity among Grade 4-6 Students in Northern Thailand
- Vulnerability Among Multi-Racial Families
- Influence of Mental Health on Preventive Behavior towards Premature - Sexual Intercourse among Junior High School Students in Thailand
Last modified: 2021-10-28 16:02:17