Oxygen Diffusion Rates of Particulate Oxygen Generators (POGs) on Cell Viability

Oxygen diffusing biomaterials provide a controlled release of oxygen while minimizing moisture loss, which is a major complication in the application of topical oxygen to wounds. We have devised an oxygen releasing biomaterial using a combination of sodium percarbonate (SPO), calcium peroxide (CPO), and polycaprolacetone (PCL) to supply a quick diffusion of oxygen delivery to hypoxic cells. Results indicate oxygen levels released via treatment enhanced cell viability despite hypoxic conditions as compared with normoxic environmental control.