The Efficacy of Xenograft Polymerized with Platelet Rich Fibrin Versus Autogenous Graft During the Secondary Alveolar Bone Grafting Of Alveolar Clefts: A Randomized Controlled Clinical Trial

Objectives: The aim of this study was to clinically and radiographically compare the effect of two types of secondary alveolar grafting, xenografts with injectable platelet rich fibrin (I-PRF) and autogenous grafts in patients with alveolar clefts. Materials and Methods: Twenty patients with unilateral alveolar cleft were divided equally into two groups: Autogenous grafts group (iliac graft) (6 males, 4 females) with a mean age of 10.5 yrs, and Xenografts polymerized with (I-PRF) group (5 males, 5 females) with a mean age of 9.8 yrs.After six months of grafting, gingival and periodontal clinical examination have been achieved at the adjacent teeth of the alveolar cleft area for all patients, while bone density was compared radiographically between alveolar cleft region and intact corresponding region within and between groups using (Cone Beam Computed Tomography) CBCT. Results: The results showed no statistical differences between both groups either clinically by measuring pocket depth, periodontal index and gingival index, or radiographically by measuring bonedensity. There was significant difference amongst bone density means in the grafted alveolar cleft region (425±120 HU) and intact corresponding region (545±125 HU) in the autogenous graft group. Conversely, there was no statistical significant difference when bone density was compared between both regions in the second group. Conclusions: The clinical and radiological success rate of the xenografts polymerized with injectable platelet-rich fibrin (I-PRF) was similar to that of the autogenous grafts when secondary grafting of the alveolar bone was done.