The Efficacy Of Medical Management In Oral Submucous Fibrosis

Aim: The Aim of the study is to analyse whether medical treatment has a potential role in the treatment of Oral Submucous Fibrosis. Materials And Methods: This is a Retrospective study where 86000 patients records were analysed and after fulfilling all inclusion and exclusion criteria, a total of 103 patients with age ranging from 21 years to 70 years suffering from Oral Submucous Fibrosis reported to Saveetha Dental College were enrolled in this study. Subjective and objective observations were recorded that includes age, gender, mouth opening before treatment, mouth opening after treatment. They were treated by administering intralesional injection of Dexamethasone 8 mg, Dexamethasone 8 mg and Hyaluronidase 1500 IU injection intralesionally biweekly for two weeks. All the datas were tabulated and statistics done using SPSS software. Results: Patients were periodically reviewed for 6 weeks and we noticed that there is improvement in the patient's mouth opening in the follow-up period over 6 weeks for both corticosteroid injections alone and also in treatment with corticosteroid and hyaluronidase injections .The increase in mouth opening is by 2-3 mm in both the groups which are considered statistically significant using paired ‘t' test and independent ‘t' test. Conclusion: Within the limitations of the study there is significant effect in the management of Oral Submucous Fibrosis with medications itself. Oral submucous fibrosis is one of important premalignant condition which if untreated may lead oral cancer. So this study helps in identifying the role of medical treatments used for treating oral submucous fibrosis. Both corticosteroid injection and Injection of hyaluronidase with dexamethasone are an effective method of managing Oral Submucous Fibrosis and can possibly eliminate the morbidity associated with Surgical Management. So this test can pave for further studies which if proven, then medical management can be performed as gold standard of treatment for initial stages of oral sub mucous fibrosis.