Comparison Of Efficacy Of Oral Bromelain and Serratiopeptidase For The Control Of Postoperative Sequelae Following Third Molar Surgery - A Comparative Study

Background: Surgical removal of Impacted third molar is widely carried out in dental practice and it is usually associated with postoperative inflammatory sequelae like pain, swelling, and trismus. The objective of the study is to assess and compare the efficacy of Oral Bromelain and Serratiopeptidase for the control of Post - operative sequelae following surgical removal of impacted third molar. Methods: A randomized, comparative clinical study was conducted on sixty patients who were undergoing impacted third molar teeth surgery, allocated in to two groups each comprising 30 patients. Conventional drugs include Cap Amoxicillin 500mg b.i.d., Tab. Metronidazole 200mg t.i.d, and Tab. Diclofenac sodium 50mg b.i.d. was given to both the groups. Group I was treated with Tab. Bromelain 200mg t.i.d along with conventional treatment for 5 days. Group II received a combination of conventional treatment and Tab. Serratiopeptidase 10 mg b.i.d for 5 days. The parameters such as measurement of pain, facial width and trismus were analysed on postoperative days 1, 2 and 7. Results: The study comprised of totally 60 otherwise healthy patients. The group of patients who received Bromelain along with Diclofenac sodium seemed to be effective in controlling post-operative sequelae like pain (p<0.05), swelling (p<0.05) but not trismus (p<0.05) when compared to the group who received Serratiopeptidase with Diclofenac sodium. Conclusion: The intensified anti - inflammatory action of bromelain, possibly by inhibiting the generation of bradykin in and negative action on the prostaglandin pathway. The present study assessed the clinical effect of bromelain and serratiopeptidase on pain, facial swelling and trismus.