Effect Of Nanoparticles Based Root Canal Disinfectants On Enterococcus Faecalis - A Systematic Review

Aim: The main goal of endodontic treatment is to prevent and to eliminate endodontic infection and allow healing of apical periodontitis. Bacteria is the main etiological factor in the development of dentinal caries and its progression to pulp and periapical disease.The complexity of the root canal system with its isthmuses, ramifications, and dentinal tubules make complete debridement of bacteria almost impossible by conventional methods and therefore irrigation is performed with the highest technical standards. Enterococcus faecalis is the bacterial species most frequently recovered from the root filled teeth and is highly associated with the endodontic failures and shows resistance to common intracanal medications. The increasing resistance of pathogenic bacteria to antibiotics is challenging which has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria. Objective: To evaluate the effect of nanoparticles based root canal disinfectants on Enterococcus faecalis. Search Strategy: A search was performed in the electronic database (i.e., PUBMED CENTRAL, Medline and Google Search) using search terms alone and in combination by means of PUBMED search builder upto October 2020. Selection Criteria: Studies were selected if they met the following criteria: In vitro/ In vivo studies, ex vivo, randomized controlled trials and Experimental studies evaluating the reduction of microbial load and biofilm biomass upon using Nanoparticles based root canal disinfectants. Data Collection and Analysis: All the studies included were based on the data extraction and analysis of the studies for quality and publication bias. The data collection form was customized. The primary outcome measure was to evaluate the microbial load when Nanoparticles based root canal disinfectants were used against Enterococcus faecalis. Main Results: The results showed that there was a significant difference in the reduction of the microbial load when nanoparticles based root canal disinfectants were used against Enterococcus faecalis. Conclusion: Based on this review, it may be concluded that nanoparticles based root canal disinfectants can be used in the reduction of the Enterococcus faecalis microbial load