Protein Evolutionary Analysis of SARS-CoV-2 Delta Plus and C.1.2 Insights Virulence and Host Immunity

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been unexpectedly evolving with inside the shape of recent versions. At least 11 recognized versions were reported. High-exceptional sequences (n = 1756) of Delta (B.1.617.2) and Delta Plus (AY.1 or B.1.617.2.1) versions have been used to decide the superiority of mutations (≥20 %) with inside the complete SARSCoV-2 genome, their co-existence, and alternate in occurrence over a duration of time. Structural evaluation changed into carried out to get insights into the effect of mutations on antibody binding. A Sankey diagram changed into generated the use of phylogenetic evaluation coupled with sequence-acquisition dates to deduce the migration of the Delta Plus version and its presence with inside the United States. The Delta Plus version had an enormous wide variety of highoccurrence mutations (≥20 %) than with inside the Delta version. The Signature mutations in Spike (A222V, G142D, and T95I) presented at a greater percentage with inside the Delta Plus version than the Delta version. Three mutations in Spike (K417N, V70F