Plasma Lipid Profile Parameters and Their Internal Ratios in Clinically Sub - Grouped Psoriasis Patients

Psoriasis is a common chronic inflammatory skin disease been considered in the recent days by dermatologists as a systemic disease with multi organ abnormalities. Increase risk of cardiovascular complications is associated with psoriasis due to an underlying dyslipidemia. A study was planned to assess the plasma lipid profile parameters and their internal ratios to assess their relationship to cardiovascular risk. A total number of 100 subjects including 50 normal control subjects and 50 psoriasis patients were studied. The psoriasis patients were clinically sub grouped into Mild (Group-1), Moderate (Group-2) and Severe (Group-3). A fasting blood sample was collected from normal control subjects and psoriasis patients for the analysis of Total cholesterol, triacylglycerol and HDL cholesterol. The levels of VLDLC, LDLC and their internal ratios was calculated. Results shows that Total cholesterol, Triacylglycerols are elevated in psoriasis patients whereas HDLC level was decreased. The ratio Triacylglycerol/HDLC was significantly elevated in psoriasis patients as well as a proportionate elevation observed in severity based psoriasis sub grouped patients suggesting this ratio may be useful in assessing cardiovascular risk in psoriasis patients.