Serum metabolic profiles changes observed post COVID-19 – Case report

COVID-19 and its consequences are still not well known. The recovery from the infection is slow and many symptoms persist for a long time. We present the influence of the SARS-CoV-2 infection on serum metabolic profiles. The profiles were obtained using NMR spectroscopy from sera collected two years prior to the infection and twice during the recovery time from otherwise healthy subject. We performed comparisons of data collected pre- with postinfection. We present the metabolites which levels were decreased after COVID-19. These metabolites are involved in metabolic pathways like the TCA cycle, purine, glycine, arginine, proline, pyruvate, taurine, alanine, glutamate, glycerophospholipids, and cholesterol metabolism, as well as fatty acid and steroid hormone biosynthesis. Studies show changes in metabolic profiles during the recovery after COVID-19 that have not been observed by standard blood tests.