NON TYPHOIDAL SALMONELLOSIS IN A PATIENT WITH ULCERATIVE COLITIS -MULTI DRUG RESISTANT SALMONELLA TYPHIMURIUM AND MOLECULAR CHARACTERISATION OF RESISTANT GENES A CASE REPORT

Background: Non typhoidal Salmonellosis are widely prevalent in developed as well as developing countries caused mostly by S.typhimurium and S enteritidis. Transmission of NTS to humans can occur by many routes including consumption of food of animal products mainly egg, poultry, undercooked ground meat and dairy products. Gastroenteritis is the most frequent manifestation, while less frequently may lead to complication like Bacteremia and Septicemia. Case summary: This is a case report of a 69 years old male admitted in Medical Gastro Enterology department with complaints of loose stools about 15-20 episodes per day with blood in some episodes and associated with diffuse abdominal pain. Culture of the stool sample detected Salmonella typhimurium which was sensitive to Cotrimoxazole & Azithromycin and resistant to Ciprofloxacin, Ampicillin & Ceftriaxone by disc diffusion method. Genotyping was done by PCR and this showed the presence of CTX-M and TEM genes. Conclusion: Non Typhoidal Salmonellae though causes self-limiting Gastroenteritis but in immunosuppressed individual it leads to focal infections & life-threatening bacteremia. The isolate from stool showed high level resistance and this could be due to increased usage of antibiotics in poultry and transfer of plasmids carrying resistance genes among enteric bacteria.