Synthesis of derivatives of tetrazoline on Creatinine and study their biological activity

In this research study we synthesized new tetrazoline from a reaction of 2-N-arylidene amino creatinine with sodium azide and 2-N-azido acetamido creatinine. The prepared compound was characterized using the FT-IR, and 1H NMR. All the physical properties and studied biological activity of synthesized compounds. The compounds 8b and 13c were given more active against gram positive, gram negative bacteria and fungi.