VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE CONTENT IN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal: International Journal of Advanced Research (Vol.9, No. 12)Publication Date: 2021-12-14
Authors : P. Santosh Kumar Wuchen Wang Lei; Zaheer Abbas;
Page : 136-146
Keywords : Telmisartan Hydrochlorothiazide RP-HPLC Simultaneousestimation Method Validation;
Abstract
A simple, accurate, precise and rapid stability indicating reverse phase High performance chromatography method was used for estimation of Telmisartan and Hydrochlorothiazide in bulk and fixed-dose combination solid oral dosage form. The proposed analytical method has been validated for specificity, Linearity, Accuracy, Precision and Robustness. The chromatography was achieved in a GL science, Inertsil C8 (Length 125x Diameter 4.0mm Particle size 5µm) column with gradient flow. The optimal chromatographic condition consisted of mobile phase pH 3.0 at a flow rate of 1.2mL/min, with a column temperature of 40°C, run time 14 minutes and detector wavelength of 270nm.
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