FORMULATION AND INVITRO EVALUATION OF SOLID DISPERSION TABLETS OF SILYMARIN
Journal: International Journal of Advanced Research (Vol.9, No. 12)Publication Date: 2021-12-14
Authors : Ayesha Naz Syeda Kulsum Mehraj Begum Mohammed Omer; Syed Naser Mohiuddin;
Page : 363-369
Keywords : Solid Dispersion Silymarin Poly Ethylene Glycol (PEG) Sodium Starch Glycollate;
Abstract
Objective: The research aims to formulate and evaluate Solid Dispersion tablets of Silymarin. Methods: Solid dispersions of Silymarin were prepared with various concentrations of carriers by using solvent evaporation method. The prepared solid dispersions were compressed into tablets by using 8 mm punch rotary tablet punching machine, with the hardness of 3.5kg /cm2.The formulated tablets were evaluated for various quality control parameters. Results: Silymarin was mixed with various proportions of excipients which showed no drug-excipients interactions. The precompression blend of Silymarin solid dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carrs index and Hausners ratio. The precompression blend of all the batches indicated good to fair flowability and compressibility. Conclusion: The tablet passed all the tests. Among all the formulations F4 formulation containing, Drug and PEG 4000 in the ratio of 1:4 showed good result that is 94.95 % in 60 minutes. As the concentration of polymer increased the drug release was increased. While the formulations containing PEG 6000 showed less release. Hence from the dissolution data it was evident that F4 formulation is the better formulation.
Other Latest Articles
- NEOLOGISM IN ENGLISH-ARABIC TRANSLATION OF INFORMATION TECHNOLOGY TERMS
- A CONCEPTUAL STUDY ON ADAB OF THE LEARNED AND THE LEARNER IN ISLAM
- AWARENESS OF ANEMIA AMONG RURAL PREGNANT WOMEN IN BAGERHAT DISTRICT OF BANGLADESH
- Oral Rehabilitation for Special Health Care Needs Egyptian Children Under General Anesthesia during the First, Second, and Third Waves of COVID-19 Pandemic: A Cross-sectional Study
- CAD/CAM System Vs. Laser Milling Zirconia For Fixed Restoration Construction; Narrative Review
Last modified: 2022-01-06 19:01:00