RESULTS OF THE IMPACT OF ANTIPROTEINASE HEMOSORBENT ON THE DYNAMICS OF THE MAIN MARKERS OF INFLAMMATION IN CHILDREN WITH SEVERE FORMS OF PERITONITIS

Background. Generalized peritonitis refers to a severe form of abdominal infection, which is based on the body's reaction in the form of generalized inflammation to infection of a bacterial nature in combination with acute signs of organ dysfunction. The levels of C-reactive protein, procalcitonin, presepsin and cytokine status in blood plasma play an important role in determining the severity of the patient's condition. Assessing the dynamics of these indicators, it is possible to judge the severity of the pathology and the adequacy of intensive care. The aim of the study was to study the effect of the antiproteinase hemosorbent "Hemo-proteazsorb" on the dynamics of the main markers of inflammation in the complex intensive care of children with generalized peritonitis. Material and methods. A prospective randomized study of 60 children with generalized peritonitis was conducted. Group I included 30 patients who underwent hemosorption through the sorbent "Hemo-proteazsorb". Group II included 30 patients who underwent traditional treatment. The examined groups were comparable by the nature of the pathology and severity of the condition. Results. After hemoperfusion, a significant decrease in the main markers of inflammation was found: C-reactive protein decreased from 83.7 (72.2; 131.3) to 12.9 (10.0; 22.0) (p=0.0003) mg/l, procalcitonin level normalized from 4.65 (2.1; 7.4) to 0.21 (0.07; 0.4) (p=0.00002) ng/ml, presepsin level decreased from 5.7 (2.5; 8.8) to 0.4 (0.3; 0.8) (p=0.25) ng/ml, the level of IL-6 decreased from 25.3 (6.0; 68.8) to 4.6 (0.9; 8.3) (p=0.000001) pg/ml. When compared in the second group, the studied indicators changed much more slowly. Conclusions. The data obtained as a result of the study indicate a decrease in the severity of the inflammatory process, a decrease in the risk of sepsis in the group of patients who underwent hemosorption, and thereby prove the effectiveness of this method.