COMPONENTS OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN THE BLOOD PLASMA AND LIVER OF RATS UNDER ADMINISTRATION OF THIOACETAMIDE
Journal: Journal of the Grodno State Medical University (Vol.19, No. 6)Publication Date: 2022-01-10
Authors : Ya. I. Novogrodskaya; M. N. Kurbat;
Page : 679-685
Keywords : amino acids; aminothiols; liver; blood plasma; thioacetamide;
Abstract
Summary. Aim. To evaluate the effect of long-term administration of thioacetamide (TAA) on the levels of free amino acids and related compounds in the blood plasma and liver of rats. Material and methods. The animals were given TAA at a dose of 200 mg/kg every other day, 4 and 12 weeks. In the blood plasma and liver of rats levels of free amino acids (AA) and low molecular weight SH-containing compounds were determined by high performance liquid chromatography. Results. Long-term administration of TAA caused hyperaminoacidemia. In the rat liver, after 4 weeks of TAA administration, the content of sulfur-containing compounds decreased, the content of proteinogenic AAs (including aromatic and branched-chain AAs) increased, and after 12 weeks the concentration of all the studied compounds increased. The levels of α-aminobutyric acid, serine, cysteate, homocysteate in the rat liver, and serine, glycine, taurine, glutathione in blood plasma, made the main endowment to the overall discrimination of the experimental groups. Conclusions. Thioacetamide damage causes amino acid imbalance, the severity of which depends on the degree of cytolysis in the liver, dysfunction of the γ-glutamyl cycle, which is confirmed by an increase in the levels of key metabolites of these reactions both in the liver and in the blood plasma.
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