NEW POLYMER BASED MODIFIED CYCLODEXTRINS GRAFTED TO TEXTILE FIBERS; CHARACTERIZATION AND APPLICATION TO COTTON WOUND DRESSINGS

This study describes the use of a new polymer based modified cyclodextrins (CDs) as a finishing agent of natural cotton fibers used in order to obtain wound dressings with improved antibacterial delivery properties. We have first synthesized the per-6-azido-Î?-CD and after the well known per-6-amino-Î?-CD was obtained via the Staudinger reduction. This synthesis was then proved by NMR and mass spectrometry characterizations. This per-aminated primary face CD was then polymerized with a citric acid. The new polymer (polyCTR-CDNH2) yielded a cross-linked polymer that chemically bonded to the cotton wound dressing fibers and was resistant to sever water washings. We report that the grafting rate of polymer of modified CDs functionalizing the cotton dressings was controlled by temperature, curing time and the CDs dilution of the impregnating bath. The functionalization was then characterized by a topographic study of dressings grafted surfaces which was approached by atomic force microscopy (AFM; non-contact mode). This characterization permitted to evaluate the roughness and the chemical heterogeneity of the grafted dressing surfaces. The grafting of the new polymer of CDs respected the original properties of treated textiles. And it can provide a functionalized medical dressing with new added properties. In fact they can be exploited to complex substances for antibacterial effect or healing purpose to facilitate the cure of the wounds. These substances will be stabilized and protected by encapsulation then they will be slowly released in contact with a wet wound. In conclusion, these results from our study offer an insight into the efficient performance of modified CDs as drug delivery systems for multiple applications in the fields of biomaterials and medical textiles.