Formulation and Evaluation of Effervescent Floating Tablet of Levofloxacin by Using Limonia acidissima and Xanthan as Natural Gum

The main objective of the study is the formulation and evaluation of effervescent floating tablet of levofloxacin by using limonia acidissima and xanthan as natural gum. The preformulation study of levofloxacin was conducted and λmax was found at 288 nm. The Effervescent Floating tablets containing levofloxacin were prepared by direct compression technique using Limonia acidissima and xanthan gum combination and varying concentrations of different ratio of polymers with Sodium bicarbonate and citric acid. All the ingredients were accurately weighed and passed through different mesh sieve no. 40. Drug, Polymer and other excipients (except talc and magnesium streate) were mixed thoroughly, passed thoroughly, passed through sieved number 40. Then, except Magnesium stearate all other ingredients were blended uniformly in glass mortar. Various formulations of effervescent floating tablet of levofloxacin F1,F2,F3,F4,F5,F6,F7 and F8 was prepared. The prepared granules was evaluated for different parameters like Bulk density, Tapped density, Angle of repose, Carr's index, Hausner's ratio, which shows the excellent flow properties of formulation. The physical characteristic of levofloxacin effervescent floating tablets (F1 to F8) such as thickness, diameter, hardness, friability, weight variation and drug content were determined and results of the formulations (F1 to F8) found to be within the limits specified in official books. The drug content of all the formulation were found to be in the range of 95.2 to 99.2. Effervescent floating tablet of different formulations were noted. With reference to buoyancy studies results it can be concluded that the batch containing limonia acidissima showed good buoyancy lag time (BLT) and total floating time (TFT). Formulation F1 and F8 containing xanthan gum showed good BLT of 28 and 78 sec and TFT of more than 12 hrs. The drug released from formulation F1 to F4 was found to be 93.2, 93.3, 94.2 and 90.1% for levofloxacin respectively. The drug released from formulation F5 to F8 was found to be 89.3, 88.1, 90.1 and 95.1 % for levofloxacin respectively. These results are indicating that has higher drug retarding ability for long duration.