Effects of Bisoprolol on Decreased Blood Pressure of Systole in Male White Rats Hypertension and Hypertension with Complications of Liver Dysfunction

Hypertension is a major public health problem and is known as an independent risk factor for cardiovascular disease. Patients with hypertension often experience complications such as liver dysfunction. Antihypertensive beta-blockers are often used by the public to treat high blood pressure and excessive heart rate. This study aimed to examine the effect of bisoprolol on decreasing systolic and diastolic blood pressure in hypertensive and hypertensive male white rats with complications of liver dysfunction. In this study, all-male white rats were made hypertensive by being induced with NaCl. Then, the group of animals complicated by liver dysfunction was induced with CCl4, then measured using a v5 + 5010 photometers. Meanwhile, the systolic blood pressures were measured using a CODA (kent scientific) instruments blood pressure gauge (Noninvasive blood pressure). The data from this study were analyzed by two-way ANOVA. It was found that the administration of bisoprolol at a dose of 2.5 mg, 5 mg, and 10 mg significantly decreased systolic blood pressure (p= 0.05). And the most effective dose is 10 mg in lowering systolic blood pressure in hypertensive and hypertensive male white rats with complications of liver dysfunction.