A Review of NS Protein Roles in Dengue Virus Transmission and their Inhibitory Factors

The Dengue virus is an RNA virus which lacks an effective vaccine. Its transmission is due to the virion?s 3 structural and 7 nonstructural proteins. The nonstructural proteins each play a specific role in impacting the interferon - mediated viral defense system, viral replication, initial viral delivery, and host body symptoms. By inhibiting these proteins, we can prevent viral replication within the host cell through the Dengue virion. The review highlights the protein functions to provide a clear scope for researchers to build vaccination trials off of, especially the protein specifics instead of a broad perspective, and develop questions for virus inhibition.