Mechanisms of Apoptosis and Molecular Basis of Carcinogenesis in Humans

Cancers is a group of diseases involving abnormal cell growth and proliferation with a potential to invade other adjunct and distant organs. According to World Health organization (WHO) 2021 report, mortality attributable to cancers was about 10 million of people. In Africa, according to GLOBOCAN 2018, there are about 36 cancer types, there were 811, 200 new case (4.5% of the world population) and 534, 000 cancer deaths (7.3% of the total world). The annual incidence of cancers in Kenya is about 47, 887 new cases with an annual mortality of 32, 987 cases, that is, 68.8% (National cancer screening guidelines, 2nd Ed). Malignancy is the 3rd most important cause of mortality in Kenya, Infections and cardiovascular taking first and second positions respectively. To combat this big public health problem, molecular understanding of cancers is key among medical practitioners in Kenya and global at large.