The Healing Effectiveness of Sesewanua Leaf Extract Cream (Cleodenronsquamatum VAHL.) against Rabbit Cuts Infected with Bacteria Staphylococcus aureus

Sesewanua plant (Clerodendronsquamatum Vahl.) is empirically used by people in several areas in North Sulawesi because it has several compounds that are thought to have antipyretic properties, one of which is flavonoids. This study aims to make the Formula of Sesewanua Leaf Extract Cream with concentrations of 1%, 3%, 5%, 7% and 9%, and determine the healing activity of Sesewanua leaf extract cream preparations on rabbit cuts infected with bacteria Staphylococcus aureus. The results of the physical properties test and stability test of the cream formula which included a stability test of 6 cycles met the requirements with test parameters namely organoleptic test, homogeneity test, pH test, spreadability test and adhesion test. The test results of the healing activity of the cream of sesewanua leaf extract on rabbit cuts smeared with bacteria Staphylococcus aureus showed that the preparation of 9% sesewanua leaf extract cream showed the most effective wound healing with a wound length of 0.1 cm. The ANOVA test results obtained a significant value of 0.788, meaning that 0.05, it can be concluded that there is no significant difference. Sesewanua leaf extract cream at a concentration of 9% has antibacterial activity that is more effective than other concentrations, as evidenced by a faster wound healing time.