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Mass Spectrometry for Analysis of Cancer Biomarker from Human Plasma
Journal: Journal of Analytical Science and Technology (JAST) (Vol.2, No. 3)Publication Date: 2011-12-15
Authors : Yeong Hee Ahn Kwang Hoe Kim Park Min Shin Eun Sun Ji Jong Shin Yoo;
Page : A135-A139
Keywords : Ultra High Resolution; Mass Spectrometry; MALDI; ESI; FTICR; Multiple Reaction Monitoring; Glycoprotein; Cancer Biomarker; Human Plasma;
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Abstract
Mass spectrometry (MS) can identify new proteins and assay the amount of the biomarker proteins that need to be validated as a viable cancer candidate. Low abundant peptides from plasma glycoprotein were identified by ultra high resolution 15T MALDI-FTICR MS with stable isotope standards and capture by anti-peptide antibodies. For the quantitation of the low abundant biomarkers, multiple reaction monitoring (MRM) method with ESI was applied for human plasma.
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Last modified: 2012-11-07 23:18:15