Treatment with MgSo4 of Babes in Term with Serious Asphyxia at Birth

Perinatal encephalopathy is a significant public health issue. It is associated with high mortality, serious morbidity and significant costs. Most of this cost is related to long - term neurodevelopmental disabilities, such as cerebral palsy (CP). Magnesium sulfate (MgSO4) is one of the most commonly used drugs in obstetric medicine. Its first reported use was in 1925 for control of eclamptic seizures. The patholphysiology of perinatal hypoxic - ischemic stroke has been extensively studied in order to find the components to be inhibited to reduce cerebral damage. Among the possible therapeutic strategies MgSO4 has been the subject of experimental studies and recently of many clinical studies.