Characterization of Synthesis and Biological Studies of Some Transition Metal Complexes of New Schiff Bases of Sulfa Drugs

The transition metal complexes find extensive applications in technology, industry and medicine. The recognition of the potential employment of transition metal complexes and chelates in therapeutic applications provide useful outlets for basic research in transition metal chemistry. Metals play a vital role in an immerse number of extensively differing biological processes. Some of these processes are quite specific in their metal ion requirements Co-ordination compounds including Schiff base ligands are significantly important because they play a vital role in life process and are well-known for their antibacterial, antifungal, anti HIV, anti inflammatory, analgesic, antitumor, antimalarial, anti dyslidmic, anti convulsent activityes. The azo methine linkage (?N=CH) is a significant feature that makes Schiff base an important biological active species as well as ligands for co-ordination. Schiff bases have been recently focused by the co-ordination chemists as versatile ligands because of their preparative accessibilities and structural varieties. The interaction between transition metal ions and biologically active Schiff base ligands become an important route in designing new metal based antibacterial and antifungal agents against different kinds of bacteria, fungi and associated viruses that become resistant to the conventional drugs. Literature review suggests that sulphonamides are well known for their wide range of biologically activity. Hydrazono group are also considered as physiologically active group. Therefore it is considered worthwhile to synthesis some new Schiff base ligands by the reaction of dike tones (derived from sulphonamides), with heterocyclic amines. The Ti (III), V (IV), Cr (III), and Co (III) complexes of newly synthesized Schiff bases have been synthesized with corresponding metal halides. The newly synthesized Schiff base ligands and complexes were characterized by elemental and spectral analysis. Geometries of the complexes were established on the basis electronic spectra of complexes and magnetic susceptibility measurement. Biological activity of synthesized Schiff bases and their Ti (III), V (IV), Cr (III), and Co (III) complexes have been evaluated against selected bacteria and fungi.