Long Term Outcomes of Children Born by ICSI in Comparison to Spontaneously Conceived Children: A Retrospective Observational Study

There are several studies which support the finding that Assisted Reproductive Technique (ART) is associated with adverse outcomes immediate neonatal period as well as later in the life of children born as a result of ICSI. Methodology: A retrospective observational study done among 50 babies born through ICSI from year 2008 to 2019 in Chettinad Hospital and Research Institute, Kelambakkam, who were followed up at baby meet clinic every year. Various parameters like mode of conception, antenatal, perinatal events were noted. Physical health, growth pattern and neuro developmental outcomes were studied and compared with spontaneously conceived children. Results: The chance of having a multiple pregnancy was found to be significantly higher in the women conceived by assisted reproductive techniques. Antenatal complications of PIH and GDM are found more commonly in women conceived by ICSI. Mean birth weight was more in children born out of natural conception. Overall in the long run children born of ICSI are significantly having a higher weight and height when compared to children who are born by natural conception. Developmental milestones were appropriate in both groups. Hearing and vision had no long term differences in both the groups. Conclusions: Contrary to the beliefs about the children born out of ART, it was observed that there was no significant difference in long term outcomes of children when compared to children born out of natural conception. So, by keeping this in mind, with a proper counselling and reassurance, ICSI can be preferred when a couple cannot conceive normally.