Formulation and Evaluation of Vaginal Disintegrating Tablet for HIV of Dolutegravir

Intra - vaginal route of administration is a route of administration where the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. Vaginal route is been used as a traditional delivery system used for the conventional delivery of several locally acting drugs like antimicrobial agents. The various types of formulations as well as the dosage forms are available for intra - vaginal drug delivery system such as tablets gels vaginal rings etc. the disease?s such as HIV or other diseases caused into the vaginal area due to causative agents like bacteria fungi etc. For efficient vaginal delivery of drugs, the delivery system should reside at the site of infection for a prolonged period of time. dolutegravir vaginal tablets were evaluated for various parameters like thickness (mm), Hardness (kg/cm2), Average weight (mg), % Drug Content,, % Friability, Effect on pH of medium, disintegration study, in - vitro release study and data treatment thereof. All the physical parameters were found to be satisfactory within the specified limits.