SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITY FOR COMPLEXES VO(II), MN(II), CO(II) AND NI(II) WITH NEW MULTIDENTATE LIGAND PROPANOIC ACID][H2L] TYPE (N2O2)

In this work, the precursor [(Z)-4-(2-hydroxy-1,2-diphenylethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol- 3(2H)-one] was synthesised from 4-aminoantipyrine and Benzoin, this precursor has been used in the synthesis of new multidentate ligand [2-((E)-4-((Z)-2-hydroxy-1,2-diphenylethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol- 3(2H)-ylideneamino)propanoic acid] [H2L] type (N2O2). The ligand was refluxed in ethanol with metal ions [VO(II), Mn(II), Co(II) and Ni(II)] salts to give the complexes of general molecular formula:[M(H2L)2(X)(Y)].B, where: M=VO(II), X=0, Y=OSO3 -2 , B=2H2O; M=Mn(II),Ni(II) ,X= H2O, Y= H2O, B=2Cl; M=Co(II), X=H2O, Y=Cl, B=Cl. . These complexes were characterised by atomic absorpition(A.A), F.T.I.R., ultraviolet visible(U.VVis)spectroscopies (1H,13C NMR for ligand only), along with condectivity, elemental microanalysis (C.H.N), chloride content and melting point measurement. These studies revealed an octahedral geometries for VO(II), Mn(II), Co(II) and Ni(II) complexes. The ligand and its complexes exhibited biological activity against the Staphylococcus aureus (G+), E-coli (G-), Pseudomonas (G-) and Proteus (G-) except [Ni(H2L)2(H2O)2].2Cl with Psedomonase has no biological activity.