A Study Comparing Post-Extubation Hemodynamic Changes with Two Different Doses of Dexmedetomidine

Introduction: Smokers are one of the at-risk group of patients prone for developing complications during extubation. Objective: Evaluation of post-extubation hemodynamic changes with two different doses of dexmedetomidine. Study design: Prospective randomized study. Method: Sixty patients of ASA physical status I and II were enrolled in the study and divided into 2 groups of 30 each. Group A included 30 patients who received 0.5 ?g/kg of dexmedetomidine in normal saline (Total volume 10 ml). Group B included 30 patients who received 0.75 ?g/kg of dexmedetomidine in normal saline (Total volume 10 ml). Results: The difference in heart rate post extubation between group A and group B was statistically significant immediately post-extubation at 0 min up to 15 min. Thereafter at 30 min up to 120 min post extubation heart rate was comparable between group A and group B. There was statistically significant difference in mean arterial pressure post extubation between group A and group B at 0 minute (Pless than0.0001), 0.5 min (Pless than0.0001), 1 minute (Pless than0.00001), 1.5 min (Pless than0.0001), 2 min (Pless than0.0001), 2.5 min (Pless than0.0001), 3 min (Pless than0.0001), 3.5 min (P=0.023), 4 min (P=0.002), 4.5 min (Pless than0.0001) up to 60 min (P=0.000). From 75 min up to 120 min, the mean arterial pressure was comparable between group A and group B Conclusion: Dexmedetomidine with dose of 0.75 ?g/kg is the best dose for maintenance of post-extubation hemodynamic changes.