Comparative clinical and radiographic evaluation of autogenous bone grafts and demineralized freeze dried bone xenograft (Osseograft) combined with PRP in the treatment of human periodontal intra-osseous defects ? 6 months study

Aim and objectives: The aim of the present study was to compare autogenous bone graft (Group - 1) and xenograft combined with PRP (Group - 2). The clinical and radiographic healing was evaluated after a period of six months in periodontal intra bony defects. Material and methods: A split mouth design was followed, where two sites in the contra lateral quadrants with probing pocket depth of ? 5 mm with radiographic evidence of bone loss at baseline were chosen. Patients were grouped as Group - 1: 7 intra bony defects treated with autogenous bone grafts, Group - 2: 7 intra bony defects treated with xenogenic grafts and platelet rich plasma (PRP). Results: The mean plaque index score, oral hygiene index score, gingival index score showed statistically significant difference from baseline to 6 months. On comparison between Group - 1 and Group - 2 from baseline to 3rd and 6th month, mean PPD, CAL, defect fill was statistically highly significant with p-value <0.001. The percentage of mean PPD, CAL, defect fill was also assessed. Conclusion: The surgical reconstructive treatment of intra-osseous defects with autogenous bone graft (Group - 1) resulted in clinically and statistically significant higher probing pocket depth reduction, clinical attachment level gain and radiographic bone fill compared to xenograft mixed with PRP (Group - 2).