EFFECT OF AQUO-N-PROPANOL SOLVENT SYSTEMS ON THE MEDICINAL EFFICIENCY OF HEAVY PROPIONATES

For highlighting the Solvent-effect of a diapolar aprotic solvent, n-propanol on the biochemical behaviour of propionate ester, the kinetics of alkali catalysed hydrolysis of butyl propionate was carried out in aquo-n-propanol solvent systems having different concentration of the organic component (n-propanol) varying from 20 to 80% (v/v) at different temperatures ranging from 20 to 40°C. The number of water molecules associated with the activated complex of the reaction were found to increase from 0.338 to 1.401 and from this, it is it inferred that n-propanol acts as structure breaker of water converting its dense form into bulky form and it changes the mechanistic path way of the reaction from bimolecular to unimolecular, From the numerical value of the kinetic temperature of the reaction, which is evaluated to be 281.0, it is concluded that there is weak but appreciable interaction between solvent and solute in the reaction media.