Comparison between Outcome of Assisted Reproductive Technique (Art) Cycles with and Without OCP Pretreatment in Infertile Women: A Randomized Clinical Trial

The objective of this randomized clinical trial was to assess the effect of pretreatment with oral contraceptive pill (OCP) on assisted reproductive technique outcomes in patient's candidate for assisted reproductive technique (ART). In a randomized clinical trial University-based infertility center, Tehran, Iran. 160 infertile patient who are candidate for IVF, randomly divided into two groups: 80 patients in OCP pretreatment group and 80 patients in non-OCP pretreatment group. The IVF protocol in all patients was standard long GnRH agonist (long protocol). The oocyte number, embryo formation, fertility rate, gonadotropin dose, ovarian cyst formation and cancelled cycles were evaluated. Oocytes number per patient in OCP group was 13.87 and in non-OCP group was 15.22, pregnancy rate in OCP group was 44.7% and in non-OCP was 31.2%, the abortion rate in OCP group was 10.5% and in non-OCP was 3.1%, that there was no significant difference between two groups, embryo formation in two groups was similar. ovarian cyst in OCP group was 2.6% and in non-OCP was 12.5% (P< 0.05) so the cancelled cycles due to ovarian cyst in OCP group was less than non-OCP group. Based on our data, OCP pretreatment have no effect on oocyte number, embryo formation, pregnancy rate and abortion, but this pretreatment can decrease the cyst formation so decrease the cancelled cycles in OCP pretreatment.