Synthesis and Identification of Some New Heterocyclic Compounds for Levofloxacin Drug Derivatives with Evaluating of Their Biological Efficiency and Antioxidant Activity

In this research study, new heterocyclic derivatives have been prepared. The most available (Levofloxacin) reacted with thionyl chloride to get acetyl chloride (S1 compound). All the synthesized compounds have been identified using FT-IR and 1H-NMR spectrum. (Scheme 1) shows that, (S1) compound in the first line treated with thiosemecarbazide to get (S2) hydrazine carbo thio amide derivative then a ring closer reaction has been made to compound (S2) by NaOH solution to get the triazole-3-thiol ring compound (S3). Second- line compound S1 treated with amino acid (glycine) to get (S4) compound. (S5) the compound has been synthesized by reacting (S4) compound with an aromatic aldehyde in the presence of acetic anhydride to get Oxazole ring (S5 compound). Second-line compound (S) treated with hydrazine hydrate to give (S6) compound then a ring closer reaction have been made using carbon disulfide and hydrazine hydrate in basic media to get (S7). Also, (S7) compound reacted with malic anhydride to prepare triazolidine di acetic acid derivative S8 compound. Also, (S) compound treated with semecarbazide and thiosemecabazide in the presence of phosphoryl chloride (POCl3) to get oxadiazole and thiadiazol containing compound respectively (S9, S10). The synthesized compounds antibacterial activity and antioxidant activity (S1-S10) were examined using the (DPPH) technique. The compounds show substantial antioxidant activity equivalent to the well-known (ascorbic acid) (IC50=31.95 g/mL) employed.