Solvent-free mechanochemical green synthesis of Schiff bases of tranexamic acid and study of their urease inhibitory and antioxidant activities
Journal: Asian Journal of Green Chemistry (Vol.6, No. 1)Publication Date: 2022-04-04
Authors : Abid Zulfiqar; Dildar Ahmed;
Page : 40-47
Keywords : Tranexamic acid derivatives; bioactivities; Green chemistry; Grinding method;
Abstract
Three Schiff bases of tranexamic acid were successfully synthesized by a mechanochemical green method, which is 4-{(5-bromo-2- hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB1), 4-{(2-hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB2), and 4-{(4-nitrobenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB3) in good yield. Their structures were confirmed based on spectroscopic data. The bases displayed considerable urease inhibitory activity with IC50 (µg/mL) 33.41, 40.64, 26.18, and 11.14 for SB1, SB2, SB3, and standard thiourea, respectively. They revealed weak antiradical activity in DPPH assay with EC50 (µg/mL) 1138, 1239, and 24248 for SB1, SB2, and SB3, respectively. In conclusion, grinding is an efficient and environmentally friendly method for synthesizing these bases, which may provide potential candidates for new medicines.
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Last modified: 2022-04-04 21:59:24