Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of Garcinia kola seeds ethanolic extract: formulation and in vivo antimalarial activity
Journal: Journal of Pharmacy & Pharmacognosy Research (Vol.8, No. 3)Publication Date: 2020-05-25
Authors : Grady K. Mukubwa Christian I. Nkanga Aristote B. Buya Jérémie K. Mbinze Rui W.M. Krause Patrick B. Memvanga;
Page : 177-190
Keywords : antimalarial activity; ethanolic extract; Garcinia kola; liquid SNEDDS; solid SNEDDS;
Abstract
Context: Garcinia kola seeds are widely used in Congolese traditional medicine to treat uncomplicated malaria. While the ethanolic extract of these seeds (GK) is reputed for oral antimalarial activity, some of its constituents have shown poor water solubility, which might compromise further phytopharmaceutical developments. Aims: To develop a self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of GK, since SNEDDS are promising vehicles for enhancing drug product solubility. Methods: GK was loaded into liquid SNEDDS (solution and suspension) and solid SNEDDS (S-SNEDDS), and the resultant formulations were characterized using dynamic light scattering and electron microscopy. The antimalarial activity of SNEDDS (200 mg/kg × 4 days, oral) was evaluated in Plasmodium berghei-infected mice using a conventional four-day suppressive test. Results: The characterization of SNEDDS formulations revealed the presence of nanosized structures of spherical morphology and negative surface charge. Data from in vivo study showed reduced parasite growth by 77.9, 73.8 and 74.2% for GK-SNEDDS solution, GK-SNEDDS suspension and GK-S-SNEDDS, respectively. The activity of GK-SNEDDS was found to be greater than that of a licensed GK-based syrup (N'sansiphos®) used at the same dose (p<0.05). Conclusions: These findings demonstrate the potential of SNEDDS formulations as a promising alternative for enhancing the antimalarial efficacy of GK following oral administration. The SNEDDS technology holds the promise of improving the oral delivery of herbal-based products for malaria therapy.
Other Latest Articles
- Ethanol extract of Parkia speciosa Hassk. loaded transfersome: Characterization and optimization
- From Lula to Bolsonaro: The immediate impacts of elections on abnormal returns in B3-listed companies
- Hydrodynamic analysis of different baffle layouts in a facultative pond to mitigate operational problems through computational fluidodynamics
- Profile of creative thinking ability in junior high school in solving flat-building geometry problems in term of van hiele’s level and students visual learning styles
- Mild peri-intraventricular hemorrhage (PIVH): factors associated with neurodevelopment and the parents' perception
Last modified: 2022-04-16 18:12:23