METFORMIN: PROPOSED MODE OF ACTION IN TYPE 2 DIABETES Niraj Khatri Sapkota

Anti hyperglycemic agents, the biguanide metformin is the brightest star, features as first-line pharmacologic treatment for type 2 diabetes in virtually all guidelines and recommendations, efficacy and tolerability of which are well tested, concluded with safety and affordable, most widely used anti diabetic drug, alone or in combination with other anti hyperglycemic agents. Unlike the sulfonylurea and insulin, metformin is not associated with weight gain or it is quite friendly to patients but its mechanism of action has been very difficult to pinpoint. This review will focus to explore all the level of proposed mechanism along with novel recruited in the field of medicine. Key words: Antihyperglycemia,Biguanide, Metformin, Sulfonylurea, Insulin