SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL UREA/THIOUREA DERIVATIVES T. Narasaiah, C*. Nagaraju

Abstract: A series of novel urea/thiourea derivatives 3a-k were synthesized by the reaction of equimolar quantities of 2-(benzo[d]thiazol-2-yl) aniline (1) in dry tetrahydrofuran (THF) and various isocyanates and thioisocyanates at room temperature in the presence of triethylamine (TEA) with high yields. All the title compounds were characterized by elemental; infrared (IR); 1H and 13C NMR; and mass spectral data analyses. Synthesized compounds were screened for their antimicrobial activity. Among the all compounds 3a, d, fe and j exhibits potential antibacterial activity. Compounds 3d and 3i shows great antifungal activity at 100μg/mL concentration. Keywords: Urea, Thiourea, Antibacterial activity, Antifungal activity