CORRELATION OF THE LEVELS OF THYROID HORMONES WITH VARIOUS COMPONENTS OF METABOLIC SYNDROME IN PATIENTS DIAGNOSED WITH METABOLIC SYNDROME

Background and Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high density lipoprotein cholesterol, raised triglyceride level in serum, hypertension and abdominal obesity. Thyroid dysfunction (TD) was found to be more frequent between patients with metabolic syndrome. MetS and its related components are associated with functional and morphological alteration of the thyroid gland. Methods: The present study was conducted at the MM Institute of Medical Sciences and Research. The study includes 300 patients with MetS as a case and 300 healthy volunteers as a control. MetS was diagnosed according to international diabetes federation. Thyroid profile was assayed in various components of metabolic syndrome. Results: It was noted that thyroid dysfunction was prevalent in 129 patients out of 300 MetS patients included in our study. Out of which, 46 patients had hypothyroidism, 18 patients had hyperthyroidism, 58 patients had subclinical hypothyroidism and 7 patients had subclinical hyperthyroidism. Interpretation and Conclusions: Our study has decided that screening must be recommended for all MetS patients to rule out thyroid dysfunction. Both MetS and thyroid dysfunction are risk factors for cardiovascular disease (CVD).