HPLC-MS-Based Metabonomics Reveals DisorderedLipid Metabolism in Patients with Metabolic Syndrome
Journal: Journal of Analytical Science and Technology (JAST) (Vol.2, No. 3)Publication Date: 2011-12-15
Authors : Shili Chen Yan Chu Xinjie Zhao Peng Gao Li Zhang Libin Zhan Guowang Xu;
Page : A173-A178
Keywords : metabonomics; metabolomics; UPLC-MS; metabolic syndrome; biomarker discovery;
Abstract
Ultra-high performance liquid chromatography/ quadrupole time of flight mass spectrometry-based metabonomics platform was employed to profile the plasma metabolites of patients with metabolic syndrome and the healthy controls. Data analysis revealed lots of differential metabolites between the two groups, and most of them were identified as lipids. Several fatty acids and lysophosphatidylcholines were of higher plasma levels in the patient group, indicating the occurrence of insulin resistance and inflammation. The identified ether phospholipids were decreased in the patient group, reflecting the oxidative stress and some metabolic disorders. These identified metabolites can also be used to aid diagnosis of patients with metabolic syndrome. These results showed that metabonomics was a promising and powerful method to study metabolic syndrome.
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