Formulation and Evaluation of Controlled Release Matrix Tablets Containing Sotalol Hydrochloride

The present research work, formulation and Evaluation of controlled release matrix tablets containing Sotalol hydrochloride for the treatment of Arrhythmiasis. Sotalol has both property of blocking beta-adrenoreceptor and prolongation of cardiac action potential and antiarrhythmic properties. The controlled release matrix tablets of sotalol hydrochloride were prepared using wet granulation technique. Physico chemical characterization of tablet and powder blends used to form the matrix tablet was carried out using a range of experimental techniques. The prepared granules were evaluated for Bulk density, Tapped density, Compressibility index, and Hausner?s ratio. The controlled release tablets were tested for weight variation, thickness, hardness and friability as per official procedure. The Instacoat EN II polymer was used as enteric coat polymer for coating the matrix tablet. The coated tablets were subjected for in-vitro drug releases studies. Dissolution studies of sotalol hydrochloride controlled release tablets in media with different dissolution media 0.1 N HCl, pH (7.4) as per US Pharmacopeia. The study showed that, drug releasein 2hr was highly affected by the coating level. The dissolution data reveled that the% of coating, ratio of polymers and concentration of Compritol 888 ATO are very important to achieve optimum formulation. The matrix tablets of Sotalol hydrochloride were prepared using wet granulation. . Tablets were tested for weight variation, thickness, hardness and friability as per official procedure. Instacoat EN II was used as enteric coat polymer for coating the matrix tablet. The coated tablets were evaluated for in-vitro drug release profile. Dissolution studies of controlled release Sotalol hydrochloride matrix tablets were carried out in different dissolution media 0.1 N HCl and pH 7.4 as per US Pharmacopiea. The results showed that, drug release in 2 hrs was highly affected by the coating level. The dissolution data revealed that the% of coating, ratio of polymers and concentration of Compritol 888 ATO are key factors to achieve optimum formulation.