Low Level of Vitamin D is Correlated with High C-Reactive Protein (CRP) and Disease Activity in Indonesian Juvenile Idiopathic Arthritis (JIA) Patients
Journal: The Indonesian Biomedical Journal (Vol.12, No. 2)Publication Date: 2020-06-01
Authors : Desy Wulandari; Wisnu Barlianto; Tita Luthfia Sari;
Page : 149-56
Keywords : vitamin D; CRP; disease activity; JADAS-27; JIA;
Abstract
BACKGROUND: Vitamin D plays essential role in the regulation of inflammation, such as in pathogenesis of Juvenile Idiopathic Arthritis (JIA). Vitamin D deficiency has been reported among JIA patients, but there were conflicting results regarding the correlation with disease activity. This study aimed to assess vitamin D serum level and its correlation with C-Reactive Protein (CRP) and disease activity in JIA patients. METHODS: Children who were diagnosed with JIA according to International League of Associations for Rheumatology (ILAR) criterias were enrolled as JIA group subjects, while age and sex-matched healthy children were enrolled as the control group subjects. Vitamin D and CRP serum level were measured. Disease activity of JIA patients was calculated by Juvenile Arthritis Disease Activity Score-27 (JADAS-27). RESULTS: Vitamin D serum level was lower in the JIA group compared to the healthy control group (p=0.000). Among 26 JIA patients, 61.5% were deficient, 30.8% were insufficient, and 7.7% had normal vitamin D. No significant different in CRP level between vitamin D group (p=0.441), but there was significant different in JADAS-27 (p=0.001). The mean of CRP and JADAS-27 were found highest in vitamin D deficiency group. Vitamin D serum level was negatively correlate with CRP (p=0.021, r=-0.452) and JADAS-27 (p=0.001 r=-0.595). CONCLUSION: Low level of vitamin D in JIA patients was inversely related to higher CRP and disease activity, suggesting that vitamin D supplementation could be have potential role in JIA treatment.
Other Latest Articles
- Chemical Composition and Bioactivity of Essential Oils of Croton blanchetianus Bailland and Sida cordifolia L. on Callosobruchus maculatus (Fabr., 1775)
- Simvastatin Improves Renal Function and Glomerulosclerosis in Ischemic-reperfusion Injury
- Comparison of Syphilis Rapid Diagnostic Test to Rapid Plasma Reagin, Treponema pallidum Haemagglutination Assay and Fluorescent Treponemal Antibody-Absorption for Syphilis and Yaws Diagnostics
- Administration of Vitamin D3 Improves Hemoglobin Level by Regulating TNF-a and IL-6 in DSS-induced Colitis Mice
- Microbiological and Biochemical Contamination Analysis of Refilled Drinking-water in Abeli, Kendari, Southeast Sulawesi
Last modified: 2022-06-03 15:16:56