Formulation, in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method

Introduction: Griseofulvin is an antifungal drug belonging to Biopharmaceutical Classification System (BCS class II) having low solubility. Objectives: To formulate, evaluate and enhance the dissolution of poorly water soluble drug Griseofulvin by using solid dispersion method. Methods: Six formulations were prepared by solid dispersion method using Polyethylene Glycol (PEG 6000) 125 mg, 0 mg, 62.5 mg, 100 mg, 25 mg, 150 mg and superdisintegrants Crospovidone 0 mg, 125 mg, 62.5 mg, 100 mg, 25 mg, 150 mg in all batches respectively. Findings: Satisfactory results were obtained from evaluation of physical characteristics of Griseofulvin tablets including: carr's compressibility index (17.5 ± 0.19% to 11.76 ± 0.67%), Hausner ratio (1.21 ± 0.01 to 1.13 ± 0.02) and post compression parameters including: thickness (5.16 ± 0.02 mm to 4.57 ± 0.19 mm), friability (0.024% to 0.322%), hardness (4 ± 0.28 kg/cm² to 5 ± 0.57 kg/cm²), disintegration time (14-870 seconds). Conclusions: F3 was best formulation among all formulated batches with in-vitro drug release 30.05% in 10 minutes, 69.21% in 30 minutes and 97.11% in 45 minutes. This indicated that formulation F3 batch with PEG 6000 of 62.5 mg and crospovidone 62.5 mg showed increased dissolution.