SACUBITRIL / VALSARTAN (ENTRESTO): A REVIEW ON DEVELOPMENT OF ANALYTICAL METHODS AND ITS ASSESSMENT IN PURE, BULK FORMULATION, BIOLOGICAL FLUIDS AND PHARMACEUTICAL PREPARATION

This Review focuses on the Recent Developments in Analytical Techniques for Estimation of Valsartan and Sacubitril Alone or in combination with other drugs in various Biological media like Human plasma and urine. The main Objective of this Review is to Unify and Interpret widely Scattered information of reported studies on Potential, Reliable and efficient Analytical Methodologies which can Estimate All the Major Components of Antihypertensive drugs. The information and suggested outlined below may facilitate and guide further Needed studies to optimise the use of Analytical Techniques like HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), GC (Gas Chromatography) etc. for determination of Antihypertensive Analytes in formulation. The presented work is focused on the use of different Analytical Methods for the estimation of Valsartan and Sacubitril in API as well as formulation. From the Reviewed Literature it is obvious that HPLC is a commonly Available method of testing in Pharmaceutical Laboratory.