Oxygen-Ozone Autohaemotherapy and Intravescical Oxygen-Ozone Insufflations in Treatment of Recurrent and Interstitial Cystitis: Preliminary Results

Introduction: Cystitis has high incidence in female population. Inflammation is responsible of irritative symptoms; it is supposed the existence of an arterial obstructive disease connected with bladder ischaemia. Direct bacterial damage and/or inflammation are responsible of the activation of ROS (radicals of oxygen) and consequent cell damage. NF-kB protein is protagonist in ROS synthesis. High levels of O2 in periphereal tissues reduce ischaemia, responsible of recurrent inflammation and increase antioxidant effects in presence of controlled oxidation. The aim of this study is the essay of anti-inflammatory effects of OOT (oxygen-ozone therapy) in chronic cystitis, employed in combined subministration. OOT properties could decrease bacterial concentration and eliminate dysuriac disturbances, reducing ischaemic effects. Methods: This study proposes a combined treatment for cystitis with oxygen-ozone AHTM (autohaemotherapy) and intravescical insufflations. It has been selected 8 Women aged 40-55 years with recurrent cystitis, associated with pain and urge incontinence. We have used certified medical OOT generator. Results: After therapies, all patients showed sterile urine and progressive reduction of symptoms with a sensible improvement of quality of life. Conclusions: Nevertheless, in a little group of patients, preliminary results could suggest the use of OOT for recurrent cystitis after failure of conventional therapies.