SOME ASPECTS OF COMPLEX PHYTOTHERAPY OF MENOPAUSAL DISORDERS IN PERMENOPAUSAL WOMEN

The article based on a complex examination of 104 women aged 46 to 50 years (mean age 48,4±0,5 years) with mild to moderate menopausal symptoms in perimenopause, the results of studying the spectrum of therapeutic activity, tolerability and safety of the use of the phytocomplex are presented. contains a combination of natural estrogen-progestin phytomolecules extracts from hop cones (120mg), rhizomes of cimicifuga racemosa (Cimicifuga racemosa) (30mg), pueraria lobata root (70mg) and pearl powder (60mg) (Lifemin), produced by «Naturex» (Avignon, France) in comparison with the drug, which is made on the basis of red clover extract and consists of active components — isoflavones: genistein, deidzein, biocanin A (Cleverol), pharmaceutical company «Jadran», Croatia. The results of the study indicate that against the background of the use of drugs of natural origin for 6 months with a high degree of reliability (P≤0,05), the general condition of the patients improves, the severity of psycho-emotional and vegetovascular disorders decreases, the drugs showed good tolerability, almost no side effects. Positive changes in the hormonal profile, plasma lipid spectrum, the absence of a negative effect on the state of the endometrium and the morphofunctional state of the mammary glands, a slightly higher clinical efficacy of the phytocomplex containing phytomones, phytoestrogens and microelements (Layfemin) was noted in comparison with the isoflavonin drugs in the context of the treatment of neurovegetative and psycho-emotional manifestations of mild to moderate menopausal syndrome in perimenopausal women were stated.