Role of Microribonucleic acid in the Carcinogenesis of Non-Small-Cell Lung Cancer
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.30, No. 1)Publication Date: 2022-03-31
Authors : M. S. Gubenko; V. I. Loginov; A. M. Burdennyy; I. V. Pronina; S. V. Khokhlova; S. S. Pertsov;
Page : 123-132
Keywords : microRNA; miRNA; non-small cell lung cancer; carcinogenesis; diagnostic significance; prognostic significance;
Abstract
INTRODUCTION: Lung cancer is the most common malignant neoplasm. Despite advances in target therapy, immunotherapy, and chemotherapy, non-small cell lung cancer remains the major cause of cancer-related death worldwide. Tumor development is a complex process that depends on the influence of environmental factors and genetic predisposition. Although oncogenic factors have received much attention, the main mechanisms for oncogenesis are still poorly understood. Thus, studying the oncogenic mechanisms, including those with the involvement of microribonucleic acid (microRNA), is important for the diagnostics and treatment of malignant neoplasms. MicroRNA (miRNA) belong to the class of small non-coding ribonucleic acids that are involved in various cellular biological processes, including epithelial–mesenchymal transition, apoptosis, proliferation, invasion, and metastatic dissemination of cancer cells. Recent publications show that the course of the oncological disease can be predicted by evaluating the expressions of some miRNAs. Therefore, miRNAs serve as promising diagnostic and therapeutic targets in oncological diseases.
CONCLUSION: This review summarizes data on the role in carcinogenesis and prognostic significance of several miRNA (i.e., miRNA-128, -4500, -222, -224, -124, -125b, -127, -129-2, -137, and -375) in non-small cell lung cancer.
Other Latest Articles
- Potentials of Using Allografts in Surgical Treatment of Popliteal Artery Aneurysms
- Intraoperative Finding of a Patient with Uterine Fibroid
- Treatment of Metastatic Brain Lesion Using Osimertinib: A Case Report
- Chronic Endotoxemia and Peculiarities of Systemic Inflammatory Response in Patients with Osteoarthrosis Requiring Primary Arthroplasty of Large Joints
- Potentials of 3D-Modeling in the Preclinical Stage of Root Needle Research
Last modified: 2023-04-03 23:11:54