VITAMIN D & OSTEOCALCIN LEVELS IN CHILDREN WITH TYPE 1 DM IN THI_QAR PROVINCE SOUTH OF IRAQ 2019

The vitamin D endocrine system is now recognized as sub serving a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth as well as immunomodulation. Both types of immunity, are regulated by vitamin D. Serum Osteocalcin (OC) is an Osteoblast-derived protein and an established biomarker of bone turnover and formation. Recently, OC has been recognized as an endocrine factor potentially regulating glucose tolerance and energy metabolism . The current study aim to estimating the vitamin D and Oc. levels in children with T1DM in Thi qar province. And to find if there is any significant relation between the control of T1DM and vitamin D and Oc. levels . Cross-sectional case -control study done in Thi qar province in Iraq and data collected from March 2019 to June 2019. The study samples comprised 52 children with type 1 DM (age 1-15 yr.) who visited Diabetic center in Thi qar province, and 52 apparently healthy children selected as a control group from the sibling of patients came with their parents to consultation unit in Bint Al Huda hospital in Nassiryia city with the same age group from (1-15 year) also. Brief clinical history was recorded from all participants. Anthropometric measurements in form of weight, height, BMI was measured. Biochemical analysis of Vit D, Oc. To all participants and HbA1c to all diabetic patients are taken . Statistical analysis was achieved by using SPSS version (25). And the result was HbA1c show significant statistical difference between the different levels of vitamin D. at the p value .019. Children with T1D.M were found to have significant association in term of p value at the 0.057 with Oc. in (-.349-.011 )(2-tailed) and this is significant negative correlation . We found most of cases above 5 yrs. and some below 5 yrs. The gender distribution doesn't found statistical association in our study. There was significant statistical association between residence and types of the samples that individuals enrolled where most of the inhabitant from urban areas. We also match cases with doses of insulin per day and we faced 9.6% newly Diagnosed as T1DM from total cases studied, 5.7% with single dose and 21.2% cases with basal bolus regime. So we conclude Vit. D deficiency is common and repletion may improve glycemic control in T1DM. And we recommend by importance of evaluation the level of vit. D and Oc. In T1DM patients and vit. D supplementation may improve glycemic control