An Open Clinical Trial to Evaluate the Efficacy of Nyagrodhadi Asthapana Basti in the Management of Prameha Upadrava with Special Reference to Diabetic Neuropathy

Background Diabetic Neuropathy DN is one of the most common troublesome micro vascular complication of diabetes mellitus. It is clinically present in 50 of all diabetic patients. The prevalence of neuropathy is related to age, duration of diabetes and the quality of metabolic control. Vascular complications, both micro and macro vascular predominate the feature of Indian diabetic patients due to delayed diagnosis and late presentation of the syndrome. Therefore many complications like neuropathy are present at the time of diagnosis.Prameha being one of the Maharoga, due to chronicity attains Upadrava Avastha DPN . DPN is a Vata Pradhana Tridoshaja Vyadhi. Lakshanas of DPN are attributed to Avaranajanya Dhatukshayaja Samprapti of Madhumeha.Objectives To evaluate the efficacy of Nyagrodhadi Asthapana Basti in the management of Prameha Upadrava with special reference to Diabetic Neuropathy.Methodology Study Design An observational clinical study with pre, mid and post test design. Intervention 30 patients of DPN were randomly selected based on the signs and symptoms of DPN. Patients were assigned into a single group and subjected to Nyagrodhadi Asthapana Basti for 8days Yogabasti pattern . Data was collected before intervention i.e. 0th day, after Basti Karma i.e. on 9th day and after Parihara Kala i.e. 25th day. Results were statistically analysed before, during and after intervention by using descriptive and inferential statistics, ‘t' test paired dependent t test, Wilcoxon Matched Pairs test.Results Statistical results on parameters showed highly significant result on symptoms of Daha burning sensation , Chumchumayana tingling sensation , Shoola Pricking pain and Dourbalya weakness on 9th day i.e. after Bastikarma and on 25th day i.e. after Pariharakala with ‘p' value of 0.0001 and insignificant result on symptom of Supti numbness with ‘p' value 1.000. Statistical result on parameters showed highly significant result in reduction of FBS, PPBS, FUS and PPUS with ‘p' value 0.0001. The result obtained in the value of Toranto clinical neuropathy scoring system showed statistically highly significant result with ‘p' value 0.0001.Conclusion The Nyagrodhadi Asthapana Basti is found to be effective and safe in the management of Diabetic peripheral neuropathy Dr. Shilpa C. Shetty | Dr. S.K. Hiremath | Dr. Doddabasayya Kendadamath "An Open Clinical Trial to Evaluate the Efficacy of Nyagrodhadi Asthapana Basti in the Management of Prameha Upadrava with Special Reference to Diabetic Neuropathy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-1 , December 2021, URL: https://www.ijtsrd.com/papers/ijtsrd47887.pdf Paper URL: https://www.ijtsrd.com/medicine/ayurvedic/47887/an-open-clinical-trial-to-evaluate-the-efficacy-of-nyagrodhadi-asthapana-basti-in-the-management-of-prameha-upadrava-with-special-reference-to-diabetic-neuropathy/dr-shilpa-c-shetty